Reigning Kenya handball Federation Champions National Cereals and Produce Board (NCPB) will be taking on Kenyatta University (KU) and Spartans on Saturday and Sunday.
The unbeaten millers lead the table have accumulated 22 points from 11 games while second placed Ulinzi have also 22 points in an unbeaten run play Spartans, who are winless from nine meetings.
Technical University of Kenya (TUK) play Desert Scorpions.
In the women, champions Nairobi Water Queens will be playing Rising Star.
The leaders have amassed 18 points while second-placed Ulinzi Sharks play Amazon as third placed NCPB play Nairobi City County.
Ulinzi confront Kenyatta University as General Service Unit 9GSU) play Inspired then Ulinzi Sharks play Water Queens when they return to face NCC.
Nairobi Water Queens will then wind their two-game programme with a clash against KU, who blanked Daystar University 57-6 in their previous encounter.